phar•ma•co•ki•net•ics
Pharmacokinetics is the study of the bodily absorption, distribution, metabolism, and elimination of drugs.
PK testing allows your doctor to understand your unique PK profile and create a treatment plan that matches your needs. Talk to your physician about obtaining your PK profile.
The aim of hemophilia A treatment is to continuously maintain factor VIII at high enough levels with regular infusions to reduce the frequency of bleeding episodes. This is known as prophylaxis, which is the standard of care for treatment of hemophilia A in the United States.
The amount of factor VIII (the drug dose) and the frequency at which it must be given to prevent spontaneous bleeds varies from person to person. PK testing allows doctors to better understand how factor VIII levels behave in your body, so they can better individualize and fine tune your treatment by defining the right dose and infusion frequency for you.
Sam, a teenage boy, has been selected for his school swimming team but is worried about his risk of bleeds if he trains more regularly.
PK testing could help to adjust his infusion schedule so that his levels of factor VIII are high enough on the days when he wants to train.*
*These are fictional scenarios for illustration only. Treatment decisions should be made by a physician on an individual basis.
PK testing involves working with your physician to measure factor VIII levels in blood samples taken from you over a period of time. With PK testing, your doctor defines your PK profile.
Like a fingerprint, a PK profile is unique for every person with hemophilia A – there is nobody else quite like you! This unique PK profile can be used to make sure that the drug is given in the right amount (the drug dose) and at the right frequency.
Marco is a 35-year-old man who loves the outdoors and hiking. Together with his doctor, they have been having difficulty finding the right infusion schedule to prevent bleeds.
PK testing could help him find the right infusion frequency to match his needs.*
*These are fictional scenarios for illustration only. Treatment decisions should be made by a physician on an individual basis.
Obtaining Your PK Profile:
Just like your personal profile with your name, address, date and place of birth, your PK profile is defined by a set of characteristics, unique to you.
Let's break them down:
Think of your factor VIII product as your car, and the PK profile (area under the curve, half-life, clearance,
and trough level) as the fuel for your car.
Ideally, you would want more gas available for your drive (higher AUC), you would want it to take longer for the gas in your tank to go from a full tank to a half talk (longer half-life), and you would want your car to burn through gas slower (slower clearance). You also want to make sure you have at least a minimum amount of gas in your tank to avoid running out of gas (right trough level).
Are you sure you want to leave the Jivi website?
Bayer is not responsible for the content viewed on other websites.
This site contains information on Jivi, which is not for use in patients less than 12 years of age or in previously untreated patients.
